01-P005 In ovo application of antagomiRs indicate a role for miR196 in patterning the chick axial skeleton through Hox gene regulation
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چکیده
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01-P005 In ovo application of antagomiRs indicate a role for miR196 in patterning the chick axial skeleton through Hox gene regulation
revealed a marked reduction in radial thickness starting at E13.5, and defective postnatal cortical layering. Whereas the former was due to neuronal apoptosis starting at E12.5, which was the earliest detectable phenotype, the latter reflected dramatic impairment of neuronal differentiation. Remarkably, the primary target cells of Dicer ablation, the neuroepithelial cells, and the neurogenic pr...
متن کاملIn ovo application of antagomiRs indicates a role for miR-196 in patterning the chick axial skeleton through Hox gene regulation.
Patterning of the vertebrate axial skeleton requires precise spatial and temporal control of Hox gene expression during embryonic development. MicroRNAs (miRNAs) are recently described modulators of gene activity, and members of the miR-196 and miR-10 families have been shown to target several Hox genes in vivo. Testing miRNA function in mice is complicated by potential redundancy between famil...
متن کاملHox patterning of the vertebrate axial skeleton.
The axial skeleton in all vertebrates is composed of similar components that extend from anterior to posterior along the body axis: the occipital skull bones and cervical, thoracic, lumbar, sacral, and caudal vertebrae. Despite significant changes in the number and size of these elements during evolution, the basic character of these anatomical elements, as well as the order in which they appea...
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چکیده ارتباط در کلاس به عوامل زیادی از جمله معلمان، دانش آموزان، برنامه های درسی و از همه مهم تر، مواد آموزشی وابسته است. در تدریس ارتباطی زبان که تاکید زیادی بر توانش ارتباطی دارد، کتاب درسی به عنوان عامل موثر بر پویایی کلاس محسوب میگردد که درس ها را از طریق فراهم آوردن متن ارتباط کلاسی و هم چنین نوع تمرین زبانی که دانش آموزان در طول فعالیت های کلاسی به آن مشغول اند، کنترل می کند. این حقیقت ک...
15 صفحه اولThe Role of Hox Genes in Axial Patterning in Hydra1
SYNOPSIS. Hox genes in bilaterians specify distinct regions along the anteriorposterior axis. A question of interest is when in metazoan evolution did this class of genes take on this function. Hox genes have been isolated from a number of cnidarian species including hydra. The expression patterns of two of them, Cnox3 and Cnox-2 have been examined in adult hydra. Cnox-3, a labial homologue, pl...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2009
ISSN: 0925-4773
DOI: 10.1016/j.mod.2009.06.006